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(Chest. 1973;63:367-370.)
© 1973 American College of Chest Physicians

Pulmonary Nocardiosis Complicating Malignant Lymphoma Successfully Treated with Chemotherapy

Jack Pinkhas M.D.1; Izhak Oliver M.D.1; Andre de Vries M.D.1; Shimon A. Spitzer M.D., F.C.C.P.2; and Eliezer Henig Ph.D.3

1 Department of Medicine D, Tel-Aviv University Medical School, Beilinson Hospital, Petah Tikva, Israel
2 Cardiopulmonary Laboratory, Tel-Aviv University Medical School, Beilinson Hospital, Petah Tikva, Israel
3 Microbiological Laboratory, Tel-Aviv University Medical School, Beilinson Hospital, Petah Tikva, Israel

A case of pulmonary nocardiosis is reported in a patient with malignant lymphoma and hypoimmunoglobulinemia. The nocardiosis initially appeared as a dense infiltration in the right upper lobe, subsequently as bilateral lung infiltrations. Nocardia asteroides was found in infralaryngeal secretion obtained by transtracheal aspiration. Treatment with sulfadiazine, trimethoprim, and sulfamethoxazole (Septrim) led to clinical recovery and disappearance of the x-ray findings. Following discontinuation of treatment there was a relapse of the lung nocardiosis roentgenologically in the initial location. The need for prolonged treatment is stressed.






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Copyright © 1973 by the American College of Chest Physicians.