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(Chest. 1973;63:20S-21S.)
© 1973 American College of Chest Physicians

Phagocytosis by Alveolar Macrophages: Pharmacologic Features

J. B. L. Gee M.D.1; F. L. Sacs M.D.1; P. McKeever M.D.1; J. S. Douglas M.D.1; and S. E. Malawista M.D.1

1 Department of Internal Medicine and Yale University Lung Research Center, Yale University, New Haven

These studies are examples of the use of pharmacologic agents to analyze some mechanisms of phagocytosis in an important pulmonary defense cell. They suggest that: 1) the metabolic features of phagocytosis may result from modification of cell membrane phospholipids, 2) AM phagocytosis depends on contractile microfilaments, and 3) cyclic AMP regulates glucose metabolism in the AM.






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Copyright © 1973 by the American College of Chest Physicians.