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(Chest. 1973;63:694-697.)
© 1973 American College of Chest Physicians

Ventilatory Effects of Aerosolized Kanamycin and Polymyxin

Kenneth J. Dickie M.D.1 and William J. de Groot M.D.1

1 Department of Internal Medicine, University of Texas Medical Branch at Galveston

Inhalation of nebulized antibiotics is associated with respiratory distress in some patients but the effect on tthe airways has not been studied. Ventilatory function was studied immediately before and 20 minutes after inhalation in patients having chronic lung disease, who were being treated with inhaled antibiotics. Kanamycin was associated with minor changes in ventilatory function but polymyxin (5 to 10 mg) was associated with significant deterioration in fucntion. The possible harmful effect on the airways should be considered when medication is given by aerosol.






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Copyright © 1973 by the American College of Chest Physicians.