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(Chest. 1973;63:727-731.)
© 1973 American College of Chest Physicians

Sympathetic Innervation of the Ductus Arteriosus in Relation to Patency

Donald E. Cassels M.D., F.C.C.P.1 and Robert Y. Moore M.D.2

1 Professor of Pediatrics, Pediatric Cardiology
2 Professor of Pediatrics, Anatomy and Medicine (Neurology)

The adrenergic innervation of the patent human ductus arteriosus was studied using the Falck-Hillarp fluorescent histochemical method for the localization of monoamines. Few adrenergic terminals were demonstrated in the muscular layers of the patent ductus arteriosus in 14 specimens examined. The innervation to the adventitia was sparse to moderate. The possibility that a developmental abnormality in the sympathetic innervation may contribute to patency of the ductus arteriosus is discussed.






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Copyright © 1973 by the American College of Chest Physicians.