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(Chest. 1973;64:137-140.)
© 1973 American College of Chest Physicians

Methylphenidate Therapy in Primary Alveolar Hypoventilation

Jerome S. Putnam M.D.1; Louis V. Kaufman M.D.1; Robert M. Michaels B.A.1; Hall G. Canter M.D, F.C.C.P.1; and Sol Katz M.D., F.C.C.P.1

1 Pulmonary Disease Division, Department of Medicine, Georgetown University School of Medicine, Washington, D.C.

Alveolar hypoventilation in patients with normal neuromuscular apparatus, chest bellows, and lung function is an infrequently described entity. Patients usually present with somnolence, lethargy, hypoxemia, hypercarbia and lack of dyspnea. The complications are life threatening, and previous modes of therapy have been largely unsatisfactory for longterm management. A 73-year-old woman, the oldest patient described with this disorder, manifested only transient response to parenteral ethamivan therapy but has been maintained with good response on oral methylphenidate.




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