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(Chest. 1973;64:465-471.)
© 1973 American College of Chest Physicians

Effect of Salbutamol on the Peripheral Circulation in Man

T. T. Zsotér M.D.1 and S. W. Epstein M.D., F.C.C.P.2

1 Associate Professor of Medicine and Pharmacology, University of Toronto
2 Assistant Professor, Department of Medicine, University of Toronto

The relative beta1 to beta2 effect of the two beta-adrenergic stimulating drugs salbutamol and isoproterenol was studied in 25 patients. Fifteen subjects had diffuse reversible airways obstruction, and ten were normal. The effect on heart rate, arterial blood pressure, forearm blood flow, arterial resistance, venous tone and peak expiratory flow rate was compared in a double-blind crossover study. In doses resulting in a similar augmentation of expiratory flow rate, isoproterenol caused a significantly greater increase in heart rate and systolic pressure than did salbutamol. Neither drug caused significant alteration in venous tone. The results were interpreted as further evidence that salbutamol is a more selective beta2 adrenergic receptor stimulant than is isoproterenol.

Submitted on December 20, 1972
Accepted on April 3, 1972






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