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(Chest. 1974;65:108-110.)
© 1974 American College of Chest Physicians

Hypercapnia during latrogenically Induced Metabolic Alkalosis

Francisco Perez-Guerra Lt Col, USAF, MC, FCCP1

1 Pulmonary Disease Service, Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland Air Force Base, Texas

A 21-year-old woman with lymphocytic lymphoma developed severe hyperuricemia and acute oliguric renal failure following antitumor chemotherapy. Large doses of sodium bicarbonate were given in an effort to minimize uric acid precipitation in the kidneys. Hypercapnia ensued as a consequence of the iatrogenically induced metabolic alkalosis in conjunction with azotemia. It is suggested that hypercapnia may be the result of either acute iatrogenically induced metabolic alkalosis or hypokalemic alkalosis when the mechanism that produces a negative cerebrospinal fluid-arterial bicarbonate gradient is altered by azotemia.







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Copyright © 1974 by the American College of Chest Physicians.