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1 Pulmonary Disease Service, Department of Medicine, Wilford Hall USAF Medical Center (AFSC), Lackland Air Force Base, Texas
A 21-year-old woman with lymphocytic lymphoma developed severe hyperuricemia and acute oliguric renal failure following antitumor chemotherapy. Large doses of sodium bicarbonate were given in an effort to minimize uric acid precipitation in the kidneys. Hypercapnia ensued as a consequence of the iatrogenically induced metabolic alkalosis in conjunction with azotemia. It is suggested that hypercapnia may be the result of either acute iatrogenically induced metabolic alkalosis or hypokalemic alkalosis when the mechanism that produces a negative cerebrospinal fluid-arterial bicarbonate gradient is altered by azotemia.
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