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(Chest. 1974;65:41-45.)
© 1974 American College of Chest Physicians

Idiopathic Pulmonary Hemosiderosis: An Electron Microscopic and Immunofluorescent Study

Richard S. Irwin M.D.1; Thomas S. Cottrell M.D.2; Konrad C. Hsu Ph.D.2; William R. Griswold M.D.2; and Henry M. Thomas III M.D.2

1 Departments of Medicine, Microbiology and Pediatrics, College of Physicians and Surgeons, Columbia University, New York City, and the Department of Pathology, New York Medical College, Valhalla, N.Y.
2 Departments of Medicine, Microbiology and Pediatrics, College of Physicians and Surgeons, Columbia University, New York City, and the Department of Pathology, New York Medical College, Valhalla, N.Y

Electron microscopic and immunofluorescent studies are reported in a patient with idiopathic pulmonary hemosiderosis, suggesting that idiopathic pulmonary hemosiderosis is distinct from other pulmonary hemorrhagic syndromes associated with antibasement membrane antibody or immune complex mediated diseases. The ultrastructural studies showed evidence of nonspecific lung injury and indirect evidence of vascular lesions. No subendothelial deposits or basement membrane lesions were seen. Immunofluorescent studies failed to reveal any evidence for localization of IgG, IgM, betaIC, Clq or fibrinogen in the lung. Investigation of platelet function showed low and low normal values of platelet retention on a glass bead column, but findings were otherwise normal.

Submitted on May 23, 1974
Accepted on August 16, 1974




This article has been cited by other articles:


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O.C. Ioachimescu, S. Sieber, and A. Kotch
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C. E. Epstein, O. Elidemir, G. N. Colasurdo, and L. L. Fan
Time Course of Hemosiderin Production by Alveolar Macrophages in a Murine Model
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[Abstract] [Full Text] [PDF]




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Copyright © 1974 by the American College of Chest Physicians.