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(Chest. 1974;65:158-162.)
© 1974 American College of Chest Physicians

The Effect of Phentolamine on Atrioventricular Conduction in Man

Lawrence Gould M.D, F.C.C.P.1; C. V.R. Reddy M.B.1; and Robert F. Gomprecht M.D.1

1 Department of Medicine, Misericordia-Fordham Hospitals, Bronx, N.Y.

The effects of phentolamine, 0.3 mg/mn given intravenously for 15 minutes, on atrioventricular and intraventricular conduction were studied in seven cardiac patients and in foru normal subjects. Recordings were made at varied heart rates, utilizing atrial pacing. Phentolamine significantly reduced the AH interval in every cardiac patient and it had no effect on the HQ or HS interval. This represents an improvementin conduction through the atrioventricular node. Phentolamine had no effect on atrioventricular and intraventricular conduction in the four normal subjects.

Submitted on April 9, 1974
Accepted on September 24, 1974






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Copyright © 1974 by the American College of Chest Physicians.