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(Chest. 1974;65:185-187.)
© 1974 American College of Chest Physicians

Serum Zinc Concentration in Acute Myocardial Infarction

Ali M. Handjani M.D., F.C.C.P.1; J. Cecil Smith Jr. Ph.D.1; John B. Herrmann M.D.1; and James A. Halsted M.D.1

1 Department of Medicine, Nemazee Hospital, Pahlavi University Medical School, Shiraz, Iran

The serum zinc concentration was examined in 18 patients, 11 with well documented myocardial infarction and 7 patients with chest pain caused by myocardial ischemia without infarction. The zinc level fell sharply in the myocardial infarction patients within a day of onset, then rose to normal values within seven to ten days. There was no comparable change from normal values in the serum zinc level in seven patients with myocardial ischemia, although two showed borderline values. In two dogs with experimentally induced infarction the serum zinc concentration level also declined markedly in a manner similar to that observed in patients with infarction. It is suggested that under appropriate conditions measurement of serum zinc concentration levels may be a useful aid for dilfferentiation of myocardial ischemia from infarction.

Submitted on October 30, 1972
Accepted on July 6, 1974




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