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(Chest. 1974;65:210-212.)
© 1974 American College of Chest Physicians

Extramedullary Hemopoiesis with Multiple Tumor-Simulating Mediastinal Masses in Hemoglobin E-Thalassemia Disease

J. L. Da Costa M.D.1; Y. S. Loh M.B.1; and E. Hanam M.B.1

1 Department of Medicine, University of Singapore, Medical Unit I and the Blood Transfusion Service, Outram Road General Hospital

Intrathoracic tumor-simulating heterotopic marrow in hemoglobin E-thalassemia is described for the first time. The characteristic feature of these extra-medullary hemopoietic masses is the uniform radiologic picture of rounded, often lobulated, paravertebral soft tissue opacities in the posterior mediastinum usually below the 7th thoracic vertebra. When this picture is associated with chronic hemolytic anemia, preoperative diagnosis is possible making surgical intervention unnecessary.






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Copyright © 1974 by the American College of Chest Physicians.