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(Chest. 1974;65:368-378.)
© 1974 American College of Chest Physicians

Left Ventricular Compliance and Abnormally Contracting Segments in Postmyocardial Infarction Patients

McKamy Smith M.D., F.C.C.P.1; Richard O. Russell Jr. M.D., F.C.C.P.1; Bolling J. Feild M.D.1; and Charles E. Rackley M.D.1

1 Division of Cardiology, Department of Medicine, University of Alabama Medical Center, Birmingham, Ala.

The relationships between left ventricular (LV) compliance, the magnitude of LV segmental disease assessed by the size of abnormally contracting segments (ACS), and ventricular size measured by ventricular volumes were examined in 38 patients who were studied by cardiac catheterization and LV biplane angiography (6-12 films/sec) within one year following myocardial infarction. LV compliance was assessed by four formulae: DgrV/DgrP (angio stroke volume/LV end-diastolic minus lowest early diastolic pressure); DgrV/ESV/DgrP (ESV = end-systolic volume); dV/dPed and dV/dPed x 1/end-diastolic volume/body surface area; percentage of ACS was measured as the akinetic or dyskinetic length along the end-diastolic perimeter on biplane LV angiograms, expressed as a percentage of the total LV diastolic perimeter. Of the four indices of compliance, DgrV/ESV/DgrP was found to have the highest correlation with percentage of ACS (r2 = .695, P = 1.5 x 10-6). This correlation (DgrV/ESV/DgrP versus percentage of ACS) was higher than the correlation between percentage of ACS and any single volume or pressure parameter. The relationship between DgrV/ESV/DgrP and percentage of ACS was significantly higher than the correlation between DgrV/ESV/DgrP and end-diastolic volume (r2 = .416, P = .002), the latter correlation primarily being due to mathematical relationships. Values for ACS above 8 percent were associated with DgrV/ESV/DgrP values which were below those obtained for normal subjects and below a theoretical normal range for DgrV/ESV/DgrP. These data suggest that left ventricular compliance is sensitive to the magnitude of LV segmental disease and is influenced less by changes in ventricular size in postmyocardial infarction patients.

Submitted on June 21, 1974
Accepted on October 15, 1974




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