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(Chest. 1974;65:488-492.)
© 1974 American College of Chest Physicians

Airway Responses of Dogs with Ragweed and Ascaris Hypersensitivity

Roy Patterson M.D.1; C. J. Mellies M.D.1; Joseph F. Kelly M.D.1; and Kathleen E. Harris B.S.1

1 Section of Allergy-Immunology, Department of Medicine, Northwestern University Medical School, Chicago

The occurrence and induction of immediate-type airway responsiveness to standardized ascaris antigen (SAA) was studied in dogs. Two of nine dogs with significant cutaneous reactivity to SAA had respiratory responses on initial aerosol challenge. Of the remaining seven dogs, six developed respiratory responses to SAA within three aerosol exposures. The respiratory responsiveness is of long duration, persisting at least four months, when the animals are exposed biweekly. Reaginic antibody against AA can be detected in the respiratory secretions of dogs sensitive to ascaris and, although this increases after antigen exposure, the increase in titer was not markedly different from the increase in serum titer. In contrast, no reaginic antibodies were detected in the RS of dogs allergic to ragweed, with respiratory responses. Respiratory function abnormalities in the canine respiratory response to ascaris were accompanied by changes in pulmonary resistance, which may precede other abnormalities during the development of respiratory responsiveness.




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