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(Chest. 1974;65:700-702.)
© 1974 American College of Chest Physicians

Pulmonary Interstitial Fibrosis Following Alveolar Proteinosis

Arnold R. Hudson M.D.1; Gerald M. Halprin M.D.2; James A. Miller M.D.3; and Kaye H. Kilburn M.D.4

1 Division of Pulmonary Medicine
2 Associate in Medicine
3 Resident in Pathology
4 Professor of Medicine

Whether permanent structural lung changes follow pulmonary alveolar proteinosis (PAP) is not known. A patient with PAP, but with no evidence of lung fibrosis, became asymptomatic spontaneously. However, 13 years after the onset of his illness he died from pulmonary insufficiency due to lung fibrosis. This suggests that the typical histologic picture of PAP is only a stage of a disease in which the end stage is fibrosis.




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Copyright © 1974 by the American College of Chest Physicians.