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(Chest. 1974;66:25-26.)
© 1974 American College of Chest Physicians

Ethambutol in Pregnancy: Observations on Embryogenesis

T. Lewit M.D.1; L. Nebel M.D.1; S. Terracina M.D.1; and S. Karman M.D.1

1 Pulmonary Ward, Shmuel Harofe Government Hospital, Beer-Yaacov; Department of Embryology and Teratology, Tel-Aviv Medical School, Chaim Sheba Medical Center, Tel-Aviv, Israel

Embryos up to the age of 12 weeks obtained from mothers receiving the usual therapeutic doses of ethambutol (ETM) did not display any signs of maldevelopment of the eye, nervous system or other organs. Further investigation of older fetuses, neonates and children from women treated with ETM during pregnancy is necessary to obtain more information on its effect on fetal development. The present report does not demonstrate adverse effects of ETM on embryonic development, but neither can it support uninhibited use of the drug during pregnancy. Therefore, in the present stage of experience, it may be advisable as a precautionary measure to treat women in the first trimester of pregnancy with first-line drugs and use ETM only in cases of intolerance or when resistance of the bacilli to these drugs occurs.

Submitted on October 15, 1974
Accepted on December 5, 1974




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