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(Chest. 1974;66:27-31.)
© 1974 American College of Chest Physicians

Coronary Collateral Circulation

Richard S. Cosby M.D., F.C.C.P.1; John A. Giddings M.D.2; and Jackie R. See M.D.3

1 Clinical Professor of Medicine (Cardiology), University of Southern California School of Medicine
2 Attending Physician, Huntington Memorial Hospital
3 Huntington Memorial Hospital and the Pasadena Cardiovascular Research Foundation, Pasadena, Calif

Collateral coronary channels represent obvious compensatory mechanisms for the delivery of nutrients to the myocardium. In spite of extensive basic research, we are still unaware of the factors determining adequate compensatory adjustments. Extensive human pathologic studies have presented a quantitative overall view, but have said little about the individual stages of adaptation. Complex multidisciplinary studies in animals have played a role but have emphasized great species variation. Human angiography is establishing a large data base but one strongly biased by clinical and therapeutic considerations. Meanwhile, clinical research is aimed at establishing the sequential morphologic changes in the development of angina, insufficiency, and infarction. Final answers concerning the significances of the collateral circulation will very likely parallel our deeper investment in research into the basic problems of the atherosclerotic process.

Submitted on October 1, 1974
Accepted on January 22, 1974






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Copyright © 1974 by the American College of Chest Physicians.