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(Chest. 1974;66:4S-7S.)
© 1974 American College of Chest Physicians

Effect of 48- and 72-Hour Oxygen Exposure on the Rabbit Alveolar Macrophage

Aron B. Fisher M.D.1; Steven Diamond B.S.1; Suzanne Mellen B.S.1; and Alan Zubrow B.S.1

1 Departments of Physiology and Medicine, University of Pennsylvania School of Medicine and Philadelphia Veterans Administration Hospital, Philadelphia, Pa.

BCG-stimulated rabbit alveolar macrophages exposed to 100 percent oxygen in vivo for 48 to 72 hours showed an increased rate of glycolysis and increased lactatepyruvate ratio without electronmicroscopic alterations or depression of phagocytosis. These changes occurred relatively late in the spectrum of pulmonary oxygen toxicity.






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Copyright © 1974 by the American College of Chest Physicians.