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(Chest. 1974;66:9S-12S.)
© 1974 American College of Chest Physicians

Common Oxidant Lesion of Mitochondrial Redox State Produced by Nitrogen Dioxide, Ozone, and High Oxygen In Alveolar Macrophages

Jeffrey R. Simons M.D.1; James Theodore M.D.2; and Eugene D. Robin M.D.2

1 Assistant Professor of Medicine, University of Utah and Staff Physician, Salt Lake City Veterans Administration Hospital
2 Department of Medicine, Stanford University School of Medicine, Stanford, Ca.

(1) Relatively low levels of three inhalable oxidants, NO2, ozone and hyperoxia over short periods, produce changes in redox states within the alveolar macrophage. (2) With NO2 there were alterations of both cytoplasmic and mitochondrial NAD+/NADH ratios without gross histologic changes. (3) Ozone and oxygen produced ratios. (4) TPGS, a water-soluble derivative of agr-tocopherol, protected the mitochondrial compartment of the cells from the effects of NO2 and O2. (5) These studies suggest a common oxident lesion involving the mitochondrial redox state.






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Copyright © 1974 by the American College of Chest Physicians.