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(Chest. 1974;66:122-132.)
© 1974 American College of Chest Physicians

The Effect of Oxygen Administration on Mixed Venous Oxygenation in Chronic Obstructive Pulmonary Disease

John C. Mithoefer M.D., F.C.C.P.1; Fred D. Holford M.D.2; and John F. H. Keighley M.B., F.C.C.P.3

1 Professor of Medicine, Director, Pulmonary Division, Medical University of South Carolina
2 Associate Professor of Medicine, Dartmouth Medical School
3 Associate Professor of Medicine, University of the State of New York at Syracuse; Chief, Pulmonary Disease Section, Syracuse Veterans Administration Hospital

This study compares the effect of the administration of various inspired oxygen concentrations on oxygenation of mixed venous and arterial blood in 33 patients with COPD at rest. Pvo2 is interpreted as reflecting the state of whole body oxygenation. The degree of oxygenation of mixed venous blood during air breathing was a reliable index of functional classification. Normal values for Pvo2 were derived from the literature which show a negative regression with age. Arterial Po2 did not reliably reflect the effect of oxygen administration on mixed venous blood in most cases; the reasons for this are discussed. A classification of patients with COPD is presented, based upon measurement of arterial Po2 and Pco2 during air breathing which serves as a guideline for oxygen therapy directed toward the correction of tissue hypoxia. The effect of oxygen administration on O2 delivery is discussed. The term coefficient of oxygen delivery is introduced (O2 delivery/Vo2); its normal values and regression with age are presented from an analysis of published data.

Submitted on October 30, 1974
Accepted on February 8, 1974




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