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1 Associate Professor of Medicine, Director, ECG Laboratory
2 Thomas Jefferson University Hospital, Philadelphia
3 The George Washington University Medical Center
An electrocardiographic-angiographic-hemodynamic correlation was conducted in 136 patients undergoing diagnostic coronary angiography. Eighty-four subjects had coronary artery disease (vessel narrowing greater than 50 percent) and were compared to 52 subjects without significant vessel obstruction (narrowing less than 50 percent). Left atrial enlargement occurred more commonly in subjects with significant coronary artery disease (p>0.001). Patients with abnormal ventricular contractility or ventricular aneurysms had a significantly higher incidence of left atrial enlargement than those with normal contractility (p<0.001). Left ventricular end-diastolic pressure averaged 18.15±10 mm Hg in patients with abnormal P waves and 9.05±5.2 mm Hg in those with normal P waves (p<0.001). The presence of abnormal P waves in patients with demonstrated coronary artery disease is highly suggestive of dyskinetic or aneurysmatic areas with elevated left ventricular end-diastolic pressure.
Submitted on July 30, 1973
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