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(Chest. 1974;66:209-211.)
© 1974 American College of Chest Physicians

Malignant Chemodectoma of the Superior Mediastinum with Elevated Urinary Homovanillic Acid

Robert W. Enquist Maj, MC1; Douglass C. Tormey Maj, MC1; Edwin H. Jenis Maj, MC1; and Raphael L. Warkel Maj, MC1

1 Pulmonary Disease Service, Hematology and Oncology Service and Pathology Service, Walter Reed Army Medical Center, Washington, DC

A 20-year-old man who presented with a metastatic lesion in his left humerus was found to have a malignant chemodectoma arising in the superior mediastinum. Analysis of urinary phenolic acid excretion revealed a marked increase in homovanillic acid, a slight increase in vanillyl mandelic acid, and normal total metanephrine excretion. The demonstration of secretory granules by electron microscopy suggests that the tumor was responsible for the secretion of catecholamines or catecholamine metabolites.






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Copyright © 1974 by the American College of Chest Physicians.