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(Chest. 1974;66:264-268.)
© 1974 American College of Chest Physicians

Localization of Immunoglobulin and Complement in Pulmonary Sarcoid Granulomas

T. Ghose M.B.1; P. Landrigan M.D., F.C.C.P.1; and A. Asif M.Sc.1

1 Departments of Medicine and Pathology, Dalhousie University Medical School, Halifax, Nova Scotia, Canada

Immunobistochemical examination of pulmonary sarcoid lesions from three patients revealed in all the presence of clumps of immunoglobulin and complement in those granulomas which were not completely fibrosed. Similar examination of lung biopsies from 36 patients Suffering from a variety of chronic lung diseases but not sarcoidosis showed clumps of immunoglobulin and complement in and around the lesions of only one patient suffering from allergic pulmonary alveolitis. This observation supports the contention that the lesions of sarcoidosis might have an immunologic basis.

Submitted on October 4, 1974
Accepted on February 12, 1974




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