Effect of Loading Dose of Procaine Amide on Left Ventricular Performance in Man

¹ Assistant Professor of Medicine, Abraham Lincoln School of Medicine, University of Illinois College of Medicine, Chicago; Assistant Professor of Medicine, Loyola Medical School, Maywood, Illinois
² Professor, Department of Pharmacology, College of Medicine, University of Illinois, Chicago

The effects of loading dose of procaine amide (Pr Am) 50 mg per minute IV for 10 minutes were assessed in 14 patients with heart disease. The mean (±SEM) of the values prior to (C) and at the end of Pr Am infusion (A) were: blood Pr Am A 42±28 (SD) µg/ml, cardiac index (CI) C 2.6 (±0.187), A 2.3 (±0.17); mean aortic pressure (AO) C 93.5 (±5.2), A 86 (±5.4); left ventricular end-diastolic pressure (LVEDP) C 17 (±2.7), A 13 (±2.4); LV peak dp/dt C 1434 (±137), A 1205.4 (±105); left ventricular stroke work (LVSW) C 51 (±6.7), A 42 (±6.2), mean pulmonary artery pressure (PA) C 31 (±3.8), A 27 (±3.2). (These differences were significant (P 0.05) for paired determination). The changes returned to control values within 30 minutes [blood Pr Am 4 µg/ml (±2.6 SD)]. There were no significant changes in heart rate and systemic arterial resistance. The data showed that the excessive dose of the drug was quite well tolerated and although parameters of cardiac function were reduced at statistically significant level at the zero time (end of procaine amide infusion) there was no morbidity.

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