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(Chest. 1974;66:352-357.)
© 1974 American College of Chest Physicians

The Arterial to End-Expiratory Carbon Dioxide Tension Gradient in Acute Pulmonary Embolism and Other Cardiopulmonary Diseases

L. Hatle M.D.1 and R. Rokseth M.D.2

1 Registrar, Department of Cardiology
2 Chief, Department of Cardiology

The arterial to end-tidal Pco2 gradient was measured in normal subjects and in the following patient groups: acute pulmonary embolism, acute myocardial infarction, left ventricular failure, pneumonia, obstructive lung disease, primary pulmonary hypertension and shock from various causes. Increased gradients were observed in 24 of 25 patients with moderate or massive embolism, in 7 of 17 with small emboli, in 20 of 34 with chronic lung disease, in 6 of 14 with shock and in 3 of 24 with left ventricular failure. By measuring in maximal expiration, high gradients in lung embolism were only slightly reduced, but approached zero in obstructive lung diseases or left ventricular failure. The patients with large emboli were thus clearly separated from other groups with acute or chronic ventilation-perfusion disturbances. No conclusive results were obtained in patients in shock.

Submitted on August 13, 1973
Accepted on April 3, 1974




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