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(Chest. 1974;66:376-377.)
© 1974 American College of Chest Physicians

Tissue Penetration of Amphotericin B in Candida Endocarditis

Ethan Rubinstein M.D.1; Eduardo R. Noriega M.D.1; Michael S. Simberkoff M.D.1; and James J. Rahal Jr. M.D.1

1 Infectious Disease Division, New York Veterans Administration Hospital and the Department of Medicine, New York University School of Medicine, New York City

Treatment of Candida parapsilosis endocarditis with amphotericin B failed to sterilize blood cultures despite serum levels which were twofold greater than the in vitro minimal inhibitory concentration. Valve tissue excised at operation continued to yield positive cultures despite prolonged immersion in high concentrations of amphotericin. These findings suggest poor penetration of amphotericin B into the vegetations of fungal endocarditis.

Submitted on November 9, 1974
Accepted on March 21, 1974




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