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(Chest. 1975;67:24S-26S.)
© 1975 American College of Chest Physicians

Functional Evaluation of Lung Mitochondria

Aron B. Fisher M.D.1

1 Departments of Medicine and Physiology, University of Pennsylvania School of Medicine, and Veterans Administration Hospital, Philadelphia

Activity of lung mitochondria was studied with a preparation of isolated mitochondria. This was correlated with responses of the isolated perfused lung as determined from surface fluorescence measurements and tissue redox couples. Lung mitochondria demonstrated substrate oxidation, respiratory control, and Ca++ activation of agr-glycerophosphate dehydrogenase. In response to oxidative inhibitors, the isolated lung showed increased surface fluorescence and increased tissue ratios of redox couples indicating reduction of pyridine nucleotides. The results demonstrate functional activity of lung mitochondria in situ.






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Copyright © 1975 by the American College of Chest Physicians.