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Chest, Vol 67, 408-410, Copyright © 1975 by American College of Chest Physicians

ARTICLES

Light chain proteinuria and cellular mediated immunity in rifampin treated patients with tuberculosis

CD Graber, CC Patrick and RL Galphin

Light chain proteinuria was found in 9 of 17 tuberculosis patients treated with rifampin. Concomitant assay of cellular mediated immunity in these patients using skin test antigen and a lymphokine in vitro test provided results that were different. Response to Varidase skin test antigen was negative for all eight tuberculosis patients tested, but there occurred a hyper-responsiveness of the lymphocytes of these eight patients to phytomitogen (PHA-P). as well as of those of seven other tuberculous patients. This last finding may be related to time of testing and/or endogenous serum binding of rifampin which could have inhibited mitogen activity for the lymphocyte.




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Copyright © 1975 by the American College of Chest Physicians.