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Chest, Vol 67, 490-491, Copyright © 1975 by American College of Chest Physicians


ARTICLES

Interaction of rifampin and warfarin

TH Self and RB Mann

A 72-year-old man who had been taking rifampin daily for several months was concurrently administered warfarin daily for ten weeks. During this period, the prothrombin time (PT) rose remarkably little as the dosage of warfarin was increased. With difficulty, satisfactory anticoagulation was achieved by giving warfarin 20 mg daily. On discontinuation of rifampin therapy, the PT increased significantly, and subsequent stabilization of the PT within therapeutic range required treatment with warfarin 7.5 mg daily.





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Copyright © 1975 by the American College of Chest Physicians.