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Chest, Vol 68, 62-64, Copyright © 1975 by American College of Chest Physicians

ARTICLES

Combined topical pulmonary and systemic gentamicin: The question of safety

KB Lake, JJ Dyke and JA Rumsfeld

Serum levels were measured in 13 subjects who received gentamicin either by inspiratory intermittent positive pressure breathing (IPPB-I) or by tracheal instillation. Only in the latter group were significant serum levels achieved. It is recommended that systemic doses of gentamicin should be reduced and serum levels closely monitored in order to avoid toxicity when the usual 3 to 5 mg/kg of IM or IV gentamicin is conbined with tracheal instillation.


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[Abstract] [Full Text] [PDF]


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Copyright © 1975 by the American College of Chest Physicians.