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(Chest. 1975;68:697-702.)
© 1975 American College of Chest Physicians

Spherulin in Clinical Coccidioidomycosis

Comparison with Coccidioidin

David A. Stevens M.D.1; H. B. Levine Ph.D.1; Stanley C. Deresinski M.D.1; and Lawrence J. Blaine 1

1 From the Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, Calif, and Stanford University, Stanford, Calif.; and the Naval Biomedical Research Laboratory, School of Public Health, University of California, Berkeley

Spherulin, an extract of the spherule phase of the fungus, Coccidioides immitis, was used in dermal sensitivity testing in 53 patients with coccidioidomycosis. Positive reactions were obtained in over two-thirds of patients with active disseminated disease and active localized disease, and with greater frequency in quiescent disease. Spherulin and coccidioidin were compared in all patients; in 17, the results were discordant. Sixteen patients were spherulin-positive and coccidioidin-negative; in one patient the reverse occurred. Spherulin appears to be a superior skin-test reagent useful in the diagnosis of coccidioidomycosis.

Submitted on March 9, 2008
Accepted on April 29, 2008






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