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(Chest. 1975;68:725-727.)
© 1975 American College of Chest Physicians

Generalized Cutaneous Reaction Associated with the Intratumor Injection of BCG

Frank C. Sparks M.D.1; Anita Highton M.D.1; John S. Hunt M.D.1; and Perry L. Scholnick M.D.1

1 From the Division of Oncology, Department of Surgery and the Division of Dermatology, Department of Medicine, School of Medicine, University of California at Los Angeles, and the Surgical Service, Sepulveda Veterans Administration Hospital, Los Angeles

BCG was injected into multiple intracutaneous tumor nodules in a patient with malignant melanoma. The melanoma nodules completely regressed, and the patient has remained in remission. Following repeated systemic and intratumor injections of BCG, she developed a marked generalized cutaneous reaction with subcutaneous granulomas. These responded to steroid and isoniazid therapy. The pathophysiology of this reaction and guidelines for immunotherapy with BCG are discussed.






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Copyright © 1975 by the American College of Chest Physicians.