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Chest, Vol 70, 681-683, Copyright © 1976 by American College of Chest Physicians

ARTICLES

Combination amphotericin B-rifampin therapy for pulmonary aspergillosis in a leukemic patient

B Ribner, GT Keusch, BA Hanna and M Perloff

Pulmonary aspergillosis developed in a 62-year-old man with acute myelogenous leukemia. Therapy with amphotericin B and 5-fluorocytosine was begun. Synergy between amphotericin B and rifampin was demonstrated in vitro, and therapy with firampin replaced 5-fluorocytosine. Progressive clearing of the pulmonary lesion ensued, suggesting in vivo efficacy as well. Further studies of patients utilizing this regimen are warranted.




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Copyright © 1976 by the American College of Chest Physicians.