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(Chest. 1977;71:24-26.)
© 1977 American College of Chest Physicians

Sudden Withdrawal of Propranolol in Patients with Angina Pectoris

Martin G. Myers M.D.1 and Gerald Wisenberg M.D.1

1 From the Division of Cardiology, Sunnybrook Hospital, Toronto, Canada

On 51 of 53 occasions, sudden withdrawal of propranolol from patients with angina pectoris produced no substantial adverse effects. Two patients experienced a recurrence of unstable angina with one man sustaining a fatal myocardial infarction ten days after propranolol withdrawal. These observations suggest that patients with previous unstable angina may be dependent upon beta-adrenoceptor blockade. Sudden cessation of propranolol for short periods may be preferable to tapering the dosage if prolonged periods of sub-optimal beta-adrenoceptor blockade are to be avoided.







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Copyright © 1977 by the American College of Chest Physicians.