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Chest, Vol 71, 587-591, Copyright © 1977 by American College of Chest Physicians

ARTICLES

Methemoglobinemia induced by a topical anesthetic spray (cetacaine)

WW Douglas and VF Fairbanks

In two seriously ill patients, cyanosis developed shortly after a topical anesthetic spray (Cetacaine) was used. In both cases the presence of methemoglobinemia was suggested by a discrepancy between the arterial oxygen tension and the oxygen saturation of hemoglobin, as measured spectrophotometrically. The characteristic responses of the spectrophotometric oximeter to blood containing different concentrations of methemoglobin are described. Physicians administering this topical anesthetic spray (Cetacaine) should be aware of the possible development of methemoglobinemia.


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 The Annals of PharmacotherapyHome page
A. C LeClaire, T. W Mullett, M S. Jahania, and J. D Flynn
Methemoglobinemia Secondary to Topical Benzocaine Use in a Lung Transplant Patient
Ann. Pharmacother., February 1, 2005; 39(2): 373 - 376.
[Abstract] [Full Text] [PDF]

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 Arch Intern MedHome page
T. J. Moore, C. S. Walsh, and M. R. Cohen
Reported Adverse Event Cases of Methemoglobinemia Associated With Benzocaine Products
Arch Intern Med, June 14, 2004; 164(11): 1192 - 1196.
[Abstract] [Full Text] [PDF]


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Copyright © 1977 by the American College of Chest Physicians.