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Chest, Vol 75, 85-86, Copyright © 1979 by American College of Chest Physicians

ARTICLES

Endocarditis due to strain of Cardiobacterium hominis resistant to erythromycin and vancomycin

RB Prior, VA Spagna and RL Perkins

Endocarditis caused by Cardiobacterium hominis was observed in a penicillin-allergic patient with a prosthetic cardiac valve who had received prophylactic therapy with erythromycin for dental extractions. The organism was resistant to erythromycin and vancomycin, with minimal inhibitory concentrations of 12.5 microgram/ml and 25 microgram/ml, respectively, but was sensitive to penicillin G, tetracycline, cephalexin, and cefaclor. This case suggests that currently recommended antibiotic prophylactic therapy for endocarditis, especially in penicillin-allergic patients, may be inadequate for unusual pathogens such as C hominis.


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