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Chest, Vol 75, 675-678, Copyright © 1979 by American College of Chest Physicians

ARTICLES

The concentration of tobramycin in bronchial secretions

MR Alexander, EM Berglund, JE Kasik, A Fox and WM Chinn

Fifteen noninfected patients received three consecutive doses of tobramycin (1.7 mg/kg intramuscularly). Serum and bronchial secretions were obtained during bronchoscopy. Microbiologic assay demonstrated that bronchial secretions containing tobramycin produced inappropriately small zone sizes when compared with serum. Also, it was shown that bronchial secretions frequently do achieve therapeutic concentrations of tobramycin at this dosage level and route of administration.




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Copyright © 1979 by the American College of Chest Physicians.