Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Order Full text via Infotrieve
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harris, J. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, J. O.

Chest, Vol 76, 156-159, Copyright © 1979 by American College of Chest Physicians

ARTICLES

Pulmonary alveolar proteinosis: abnormal in vitro function of alveolar macrophages

JO Harris

Pulmonary alveolar proteinosis is characterized by the accumulation of granular proteinaceous material within the alveoli of the lung. It is well established that patients with pulmonary alveolar proteinosis have a high incidence of complicating pulmonary infections, which suggests that the function of the alveolar macrophages is abnormal. To investigate the function of these cells, they were obtained from two patients by pulmonary lavage with physiologic saline solution and were incubated with Staphylococcus aureus in vitro. The decline in viable organisms from the culture was measured and compared with results obtained with normal alveolar macrophages. On the basis of decreased phagocytosis, results indicate that pulmonary alveolar macrophages from these patients had defective antibacterial function.


This article has been cited by other articles:


Home page
 BloodHome page
K. Uchida, K. Nakata, B. C. Trapnell, T. Terakawa, E. Hamano, A. Mikami, I. Matsushita, J. F. Seymour, M. Oh-eda, I. Ishige, et al.
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
Blood, February 1, 2004; 103(3): 1089 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. F. Seymour and J. J. Presneill
Pulmonary Alveolar Proteinosis: Progress in the First 44 Years
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 215 - 235.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P. L Shah, D. Hansell, P. R Lawson, K. B M Reid, and C. Morgan
Rare diseases bullet 6: Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis
Thorax, January 1, 2000; 55(1): 67 - 77.
[Full Text]

Home page
 BloodHome page
U. Dirksen, U. Hattenhorst, P. Schneider, H. Schroten, U. Gobel, A. Bocking, K.-M. Muller, R. Murray, and S. Burdach
Defective Expression of Granulocyte-Macrophage Colony-Stimulating Factor/Interleukin-3/Interleukin-5 Receptor Common beta  Chain in Children With Acute Myeloid Leukemia Associated With Respiratory Failure
Blood, August 15, 1998; 92(4): 1097 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-Q. SHEN, C.-X. DUAN, Z.-Y. LI, and Y. SUZUKI
Effects of Proteinosis Surfactant Proteins on the Viability of Rat Alveolar Macrophages
Am. J. Respir. Crit. Care Med., November 1, 1997; 156(5): 1679 - 1687.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by the American College of Chest Physicians.