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Chest, Vol 76, 235-236, Copyright © 1979 by American College of Chest Physicians

ARTICLES

Combined intravenous miconazole and intrathecal amphotericin B for treatment of disseminated coccidioidomycosis

SJ Davis and WH Donovan

A patient received a previously unreported combination of intravenous miconazole and intrathecal amphotericin B for the treatment of disseminated coccidioidomycosis with central nervous system involvement. After first having been treated with amphotericin B, followed by a course of miconazole therapy, the patient responded with remarkable clinical and serologic improvement to the combination of intrathecal amphotericin B and intravenous miconazole. The combination should be considered in the treatment of disseminated coccidioidomycosis with central nervous system involvement.




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Copyright © 1979 by the American College of Chest Physicians.