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Chest, Vol 76, 571-575, Copyright © 1979 by American College of Chest Physicians

ARTICLES

Hemodynamic improvement following a single dose of oral phentolamine. Administration in patients with chronic low output cardiac failure

R Schreiber, PT Maier, RM Gunnar and HS Loeb

Hemodynamic studies were made in 15 patients with chronic low output cardiac failure before and following a single dose of oral phentolamine (150 mg). After two hours significant (P less than .05) reduction occurred in mean pulmonary, wedge and right atrial pressures and increases in cardiac index and heart rate. In ten patients studied at four hours, wedge pressure remained significantly reduced (-18 percent) and cardiac index significantly increased (+19 percent) from control values. Oral phentolamine results in significant hemodynamic improvement in patients with severe heart failure. Duration of effect for at least four hours after a single dose suggests that intermittent oral therapy may be useful in the management of such patients.


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