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Chest, Vol 77, 695-697, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Minimal-change nephropathy and malignant thymoma

S Varsano, I Bruderman, JL Bernheim, M Rathaus and B Griffel

A 56-year-old man had fever, precordial pain, and a mediastinal mass. The mass disappeared two months later and the patient remained asymptomatic for 2 1/2 years. At that time a full-blown nephrotic syndrome developed, with minimal-change glomerulopathy. The chest x-ray film showed the reappearance of a giant mediastinal mass. On biopsy of the mass, malignant thymoma was diagnosed. Association between minimal- change disease and Hodgkin's disease is well known, while the association with malignant thymoma has not been previously reported. The relationship between malignant thymoma and minimal-change disease is discussed, and a possible pathogenic mechanism involving cell- mediated immunity is proposed.




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Copyright © 1980 by the American College of Chest Physicians.