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Chest, Vol 78, 587-590, Copyright © 1980 by American College of Chest Physicians

ARTICLES

Diagnostic value of carcinoembryonic antigen in exudative pleural effusions

JM McKenna, AJ Chandrasekhar and RE Henkin

Elevated pleural fluid (PF) and plasma (PL) carcinoembryonic antigen (CEA) levels (ng/ml) were more frequently found with malignant than benign exudative effusions, but with a low true-positive rate for malignancy in general. Adenocarcinomatous effusions differed from other malignant and benign effusions in the frequency and degree of elevation of PF and PL CEA levels. A PF > 20 had a sensitivity of 91 percent and a specificity of 92 percent as a screening test for adenocarcinomatous effusions. A PF CEA > 55 or PL CEA > 10 were present only with malignancy and 98 percent specific for adenocarcinoma.




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Copyright © 1980 by the American College of Chest Physicians.