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Chest, Vol 82, 793-794, Copyright © 1982 by American College of Chest Physicians

ARTICLES

Rapid attenuation of response to nifedipine in primary pulmonary hypertension

BA Wood, F Tortoledo, JC Luck and WH Fennell

In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug- related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg.




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Copyright © 1982 by the American College of Chest Physicians.