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Chest, Vol 83, 302-304, Copyright © 1983 by American College of Chest Physicians

ARTICLES

Peripheral alpha 1- and alpha 2-adrenoreceptor mechanisms in blood pressure control

JL Reid, CA Hamilton and JA Hannah

Peripheral alpha-adrenoreceptors can be characterized as alpha 1 or alpha 2, depending on their affinity for agonists and antagonists. Alpha 2-adrenoreceptors, probably located postsynaptically on smooth muscle of resistance vessels, contribute to the pressor responses to intravenously given norepinephrine. Studies with the noncompetitive alpha-adrenoreceptor antagonist phenoxybenzamine suggest that there are important differences in the regulation of the two types of receptors. The slower recovery alpha 1-adrenoreceptor binding sites and the more rapid recovery of responses suggest the presence of "spare" alpha 1- but not alpha 2-adrenoreceptors.




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Copyright © 1983 by the American College of Chest Physicians.