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(Chest. 1983;83:302-304.)
© 1983 American College of Chest Physicians

Peripheral agr1- and agr2-Adrenoreceptor Mechanisms in Blood Pressure Control

John L. Reid M.D.1; Carlene A. Hamilton 1; and John A. M. Hannah 1

1 From the University Department of Materia Medica, Stobhill, General Hospital, Glasgow, Scotland

Peripheral agr-adrenoreceptors can be characterized as agr1 or agr2, depending on their affinity for agonists and antagonists. Alpha2-adrenoreceptors, probably located postsynaptically on smooth muscle of resistance vessels, contribute to the pressor responses to intravenously given norepinephrine. Studies with the noncompetitive agr-adrenoreceptor antagonist phenoxybenzamine suggest that there are important differences in the regulation of the two types of receptors. The slower recovery agr1-adrenoreceptor binding sites and the more rapid recovery of responses suggest the presence of "spare" agr1- but not agr2-adrenoreceptors.






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Copyright © 1983 by the American College of Chest Physicians.