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(Chest. 1983;83:349-351.)
© 1983 American College of Chest Physicians

Reversal of the Central Hypotensive Effect of Clonidine by Intracisternal Curare-like Agents

Danita Tsoucaris-Kupfer M.D.1 and Henri Schmitt M.D.1

1 Département de Pharmacologie, Faculté de Médecine Broussais, Hôtel-Dieu, Paris, France

Administration of tubocurarine, pancuronium, gallamine, or decamethonium into the cisterna magna of chloralosed dogs induced a rise in blood pressure. Clonidine (3 µg/kg) administered into the cisterna magna after tubocurarine, pancuronium, or gallamine significantly increased blood pressure; no significant change was found after decamethonium. The pressor response to clonidine after tubocurarine was antagonized by injection of the agr1-adrenoceptor-blocking agents AR-C 239 or prazosin into the cisterna magna at low doses prior to injection of clonidine. Yohimbine, a preferential agr2-adrenoceptor-blocking agent was ineffective. It is suggested that the pressor response to intracisternal clonidine after intracisternal tubocurarine is due to stimulation of agr1-adrenoceptor stimulation.






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Copyright © 1983 by the American College of Chest Physicians.