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(Chest. 1983;83:403-404.)
© 1983 American College of Chest Physicians

Guanfacine Alone and in Combination Therapy in the Treatment of Moderate and Severe Hypertension

Y. K. Seedat M.D.1

1 Professor and Head of Medicine, University of Natal, Durban, Republic of South Africa

This study of guanfacine in 27 patients suffering from moderate-to-severe hypertension showed a satisfactory blood pressure control in 26 patients. Twenty-one of the 27 patients completed a one-year clinical trial with good blood pressure response. The new drugs, acting through the stimulation of the central agr-adrenoceptors, are useful in patients suffering from moderate-to-severe hypertension. They are a good alternative to adrenergic neuron-blocking drugs, methyldopa, or β-blockers, and useful in patients with refractory hypertension where conventional therapy has failed.






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Copyright © 1983 by the American College of Chest Physicians.