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Chest, Vol 83, 480-484, Copyright © 1983 by American College of Chest Physicians

ARTICLES

Effect of oral disopyramide therapy on left ventricular function

AC Greene, AS Iskandrian, AH Hakki, SA Kane and BL Segal

To study the effect of oral disopyramide therapy on left ventricular function, a subject of some controversy, we obtained first-pass radionuclide ventriculograms with a multicrystal gamma camera in 19 patients with or without therapy. Our findings demonstrated that disopyramide causes deterioration in left ventricular function in patients with abnormal ejection fractions. This effect is rarely recognized clinically and occurs despite safe therapeutic serum levels.




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Copyright © 1983 by the American College of Chest Physicians.