Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gelb, A. F.
Right arrow Articles by Taylor, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gelb, A. F.
Right arrow Articles by Taylor, C. R.

Chest, Vol 84, 148-153, Copyright © 1983 by American College of Chest Physicians

ARTICLES

Immune complexes, gallium lung scans, and bronchoalveolar lavage in idiopathic interstitial pneumonitis-fibrosis

AF Gelb, RB Dreisen, JD Epstein, JD Silverthorne, Y Bickel, M Fields, WA Border and CR Taylor

We obtained results of lung immune complexes (LIC), circulating immune complexes (CIC), 48-hour gallium lung scans (scans), bronchoalveolar lavage (BAL), and pulmonary function tests in 20 patients with idiopathic interstitial pneumonitis-fibrosis. Sixteen patients had predominantly interstitial (13 cases UIP) and/or intraalveolar (3 cases DIP) cellular disease (group 1). Prior to corticosteroid therapy in group 1, scans were positive in 75 percent, CIC were elevated in 86 percent, LIC were present in 64 percent, and BAL was abnormal in 90 percent. Duration of follow-up after treatment was 3.5 +/- 1.0 year. In group 1 after treatment with corticosteroids in 13 patients and corticosteroids and penicillamine (three patients) and plasmapheresis (one patient), only four patients remain stable or improved. After corticosteroid therapy, elevated CIC returned to normal values despite progressive patient deterioration. In three patients, lung immune complexes were still detected after circulating immune complexes had returned to normal after corticosteroid therapy. In group 2 were four patients with fibrotic disease; scans and CIC were uniformly negative, LIC were weakly present in only one patient, and BAL was abnormal in all. Despite corticosteroid therapy, all have died or deteriorated. These results suggest that positive gallium lung scans, BAL, circulating immune complexes, and to a lesser extent, lung immune complexes are associated with the cellular phase of interstitial pneumonia, but do not reliably identify a corticosteroid-responsive group.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
S. P. Hart, K. M. Alexander, and I. Dransfield
Immune Complexes Bind Preferentially to Fc{gamma}RIIA (CD32) on Apoptotic Neutrophils, Leading to Augmented Phagocytosis by Macrophages and Release of Proinflammatory Cytokines
J. Immunol., February 1, 2004; 172(3): 1882 - 1887.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. G. Nicholson, L. G. Fulford, T. V. Colby, R. M. du Bois, D. M. Hansell, and A. U. Wells
The Relationship between Individual Histologic Features and Disease Progression in Idiopathic Pulmonary Fibrosis
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 173 - 177.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Ishizaka, N. Hasegawa, K. Nakamura, Y. Takagi, M. Takano, K. Yamaguchi, and A. Kubo
Usefulness of Pulmonary Vascular Leakiness Assessment in Interstitial Pneumonitis
Chest, May 1, 2001; 119(5): 1455 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A.-L. A. KATZENSTEIN and J. L. MYERS
Idiopathic Pulmonary Fibrosis . Clinical Relevance of Pathologic Classification
Am. J. Respir. Crit. Care Med., April 1, 1998; 157(4): 1301 - 1315.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by the American College of Chest Physicians.