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Chest, Vol 85, 133-135, Copyright © 1984 by American College of Chest Physicians

ARTICLES

Amiodarone-induced hypersensitivity pneumonitis. Evidence of an immunological cell-mediated mechanism

GM Akoun, S Gauthier-Rahman, BJ Milleron, JY Perrot and CM Mayaud

Interstitial pneumonitis developed in a patient who had received a cumulative dose of 985 g of amiodarone in nine years. No other cause for pneumonitis was found. The following findings favor an immunologic mechanism of hypersensitivity due to amiodarone: positive skin and basophil degranulation tests with amiodarone; lymphocytosis and inverted ratio of helper/suppressor T lymphocytes in bronchoalveolar lavage fluid; secretion of leukocyte inhibitory factor, as shown by the inhibition of migration of peripheral blood leukocytes; and positive lymphoblastic transformation in the presence of amiodarone.


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Copyright © 1984 by the American College of Chest Physicians.