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Chest, Vol 85, 739-743, Copyright © 1984 by American College of Chest Physicians

ARTICLES

Plasmapheresis in the treatment of ventilator-dependent myasthenia gravis patients. Report of four cases

DR Gracey, FM Howard Jr and MB Divertie

During a 42-month period, we used plasmapheresis to treat four cases of myasthenia gravis with refractory respiratory failure. All four patients were ventilator dependent for prolonged periods and were not responding to management with cholinesterase inhibitors and corticosteroids. All four patients rapidly responded to the plasmapheresis; respiratory muscle strength returned sufficiently to allow discontinuation of assisted mechanical ventilation and removal of the artificial airway. In our experience, plasmapheresis is indicated in the treatment of the myasthenia gravis patient with respiratory failure which is refractory to conventional drug therapy.




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Copyright © 1984 by the American College of Chest Physicians.